2. Increased risk of deformation in close pairings with relatives, which surely turned up early in mankinds history, and probably got noticed. (Ever notice how Zong's family alway's have a lot of hare-lips and real dumbass's)

3. Robert Heinlien, in "Time Enough for Love" postulated a time where the genetic chart for anyone who wanted it could be obtained, read, and, barring any bad news within the chart, it might be "genetically" no problem with siblings having offspring with each other, while two complete strangers may be genetically mismatched, with defective recessives reinforcing each other producing bad offspring.