Well, as an example, I can accept that, say, a persons experiences at the hands of others could "cause" him to be predisposed to misanthropy.
But he still chooses a misanthropic action over one that isn't. He could choose to act other than his predisposition suggests.
The "cause" of his misanthropy though, was itself caused by that other person's experiences though. If the other person had been having a good day instead, he might have acted differently. If he had, the other guy wouldn't become a misanthrope.
Nothing made it inevitable that the original person would take out his frustration on this particular person. It could as easily have gone another way. That's why the variable of human action is dominant. Everything in the universe could have conspired to create that bad day. But the guy could have chosen to treat the other well, instead of poorly.